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Related Issues: 32934
I have been able to recreate the issue. Starting a new character with perception of 5 I allowed myself to become dehydrated setting my stat value to (-)1 with the debuff active in the 'active effects' section in the pip boy. After rehydrating both in the pip boy and through the quick use favorites '+' I found that in both cases I was able to remove the debuff from the 'active effects' but my stats remained a (-)1.
Unfortunately survival mode buffs and debuffs becoming permanent is not something we can fix. It's an engine issue Bethesda needs to take up.
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