Similar to how "Weakness to Magic" in Oblivion would amplify positive magical effects on the player provided it came from a spell with at least 1 negative effect, it would appear that Skyrim's "Weakness to Poison" effect can amplify positive effects applied to the user through a poison.
Additionally, negative effects on potions consumed by a player will stack provided that they have distinct values or effects (10% weaker to poison will stack with 11% weaker to poison)
So a player could create several distinct potions that included a weakness to poison effect, then apply a poison with a positive effect on a weapon, provide that to an ally through trade or a stranger through reverse pickpocket, provoke them to attack, and have the effects of that poison amplified infinitely.
If that positive effect is Fortify Enchanting, you can lock in ultra powered stats indefinitely, including potions, enabling the player to have god-like stats that were attainable using the famous Restoration loop bug.
It's also worth noting that the 100% Weakness to Magic effect provided by the Apprentice Standing Stone will amplify negative effects in the potions you drink, which significantly speeds up this process. For the purposes of testing however, I'll supply you a series of steps that involve the least amount of outside effects as possible.
I was able to recreate this loading SSE with only the Unofficial Skyrim SE patch, under these circumstances:
-My Character's race was Nord.
-Game Difficulty was Adept.
-Alchemy was at 100, with the following perks: Alchemist (5/5)
-Enchanting was at 100, with the following perks: Enchanter (5/5)
-I recruited Jenassa from the Drunken Huntsman in Whiterun to apply the poison on me.
-I went to Dragon's Reach to access Farengar's Alchemy and Enchanting Stations.
-I spawned in the following items: Abacean Longfin (5), Charus Eggs (5), Vampire Salts (5), Cyrodillic Spadetail (5), Snowberries (5), Spider Eggs (5), Spriggan Sap (5), Grand Soul Gem (Grand) (5), Roughspin Tounic (5),
-Using Abacean Longfin, Chaurus Eggs, and Vampire Salts, I made a Potion of Invisibility (Invisible for 48 seconds,
Target is 24% weaker to poison damage for 30 seconds)
-Using Abacean Longfin, Chaurus Eggs, and Cyrodilic Spadetail, I made a Potion of Restoration (Restoration Spell are 48% stronger,
Target is 24% weaker to poison damage for 30 seconds)
-Using Snowberries, Spider Eggs, and Sprigan Sap, I made a Poison of Damage Magika Regen (Reduced Magicka Regeneration by 100%,
Improved Enchanting by 12%).
-I consumed the Potion of Restoration, which gave me the initial 24% weakness to poison, and followed up with the Potion of Invisibility, which gave me an additional
29% weakness to poison. This is because the initial 24% weakness from the first potion was applied to the subsequent 24% weakness in the second potion, and both effects stacked, bringing us to a grand total of 53% weakness to poison.
-I then gave Jenassa a dagger coated with my Poison and provoked her to strike me. My Active Effects showed that not only did my Magika Regeneration get stunted by an additional 53% (-153% regeneration total), but my enchanting effect went up by 53% as well (12% to 18% stronger enchantments).
-I tested this effect on enchanted items, by first enchanting a Roughspin Tounic with Fortify Magika Regen, using a Grand Soul Gem (filled with a Grand Soul) without any enchanting buffs, and then with an Enchanting Buff applied only through the poison, and finally with the poison amplified by my two Weakness to Poison Potions.
Results for those are as follows:
No Buff: Magika Regenerates 50% faster.
Poison Buff only: Magika Regenerates 56% faster.
Potion + Poison Buffs: Magika Regenerates 59% faster.
This is consistent with my theory, as 56% is roughly 12% greater than 50% and 59% is 18% greater than 50%.
While this may seem insignificant, it can be game breaking when you introduce 10-20 distinct weakness to poison potions that are all doubled by the Weakness to Magic effect from the Apprentice Stone.
I've attached Screenshots in the following order:
1. Poison of Damage Magicka Regen.
2. Potion of Fortify Restoration.
3. Potion of Invisibility.
4. My Active Effects before applying anything.
5. The effect of the Fortify Restoration Potion I consumed
before consuming the other potion.
6. The effect of the Fortify Invisibility Potion I consumed
after consuming the Restoration Potion. Notice the weakness to poison effect was increased but the Invisibility effect remained the same.
7. Active Effect applied on me after I drank both potions and goaded Jenassa to poison me.
8. Enchanted Roughspun Tunic before applying any buffs.
9. Enchanted Roughspun Tunic after applying just the poison.
10. Enchanted Roughspun Tunic after applying both Potions and the Poison.
Final Note: I'm surprised I don't see this anywhere on the UESP Wiki or mentioned in any of the bug forums. I figured someone else would have found this by now. I wonder if some consider it an intended feature.
I'm calling this a bug because I doubt that devs intended for positive effects on poisons to be considered "Poisons" that are amplified by a weakness to poison effect, which is further evidenced by the fact that "Weakness to Magic" does not apply to positive effects on potions. "Weakness" in general is intended to be entirely a negative effect, and this bug turns it into a gamebreaking route to God-Mode.
Thank you for your time, and I really appreciate the work you do, please let me know if you need anything else!
Attached Files:
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Issue Data
Issue #28974: Gamebreaking Weakness to Poison Exploit