Player:
"Did I hear you say something about a cursed child?"
Idesa Sadri:
"Hmm. Yes, it is quite sad. A young boy, Aventus Aretino, lost his mother recently, and was sent to an orphanage. But he has returned home, and people have heard strange chanting. They say it's the Black Sacrament, the ritual to contact the Dark Brotherhood. Why a little boy would want to contact a group of murderers is beyond me, but he is inviting evil into this city."
This dialogue topic continues to be available as a conversation topic with Idesa well into the Dark Brotherhood questline, and (in my case) even after killing the Emperor. I'm thinking that I probably didn't speak with her after her scene with Grimvar played out when first visiting Windhelm. Maybe I'm wrong on this, but it seems like it shouldn't be available after DB01 (Innocence Lost) has been completed. You could argue that she isn't aware that Aventus left Windhelm for Riften, but regardless it doesn't make a lot of sense beyond that point.